{"id":21569,"date":"2023-10-10T10:57:29","date_gmt":"2023-10-10T10:57:29","guid":{"rendered":"https:\/\/www.ginefiv.com\/?post_type=treatment&#038;p=21569"},"modified":"2024-04-10T21:24:07","modified_gmt":"2024-04-10T21:24:07","slug":"macs","status":"publish","type":"treatment","link":"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/macs\/","title":{"rendered":"MACS"},"content":{"rendered":"<div class=\"wp-block-cover alignfull\" style=\"min-height:80vh;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-20 has-background-dim\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"999\" height=\"714\" class=\"wp-block-cover__image-background wp-image-459\" alt=\"\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/06\/inseminacion_hero.webp\" data-object-fit=\"cover\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/06\/inseminacion_hero.webp 999w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/06\/inseminacion_hero-300x214.webp 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/06\/inseminacion_hero-768x549.webp 768w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/06\/inseminacion_hero-350x250.webp 350w\" sizes=\"auto, (max-width: 999px) 100vw, 999px\" \/><div class=\"wp-block-cover__inner-container is-layout-constrained wp-block-cover-is-layout-constrained\"> <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <p class=\"has-large-font-size\">Assisted reproduction<\/p>    <h1 class=\"wp-block-heading\">The MACS technique (Magnetic Activated<br>Cell Sorting)<\/h1>    <p class=\"has-medium-font-size\">As you will find out below, the MACS technique enables us to optimise the selection of spermatozoa before they are used in our <a href=\"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/\">assisted reproduction<\/a> treatments.<\/p> <\/div>    <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <ul class=\"wp-block-list\"> <li><a href=\"#diferencias\">Diferencias entre Mini FIV y FIV convencional<\/a><\/li>    <li><a href=\"#ventajas\">\u00bfCu\u00e1les son las ventajas e inconvenientes de la Mini FIV?<\/a><\/li>    <li><a href=\"#video\">V\u00eddeo explicativo<\/a><\/li>    <li><a href=\"#tecnica\">\u00bfCu\u00e1ndo est\u00e1 indicada la t\u00e9cnica Mini FIV?<\/a><\/li> <\/ul> <\/div> <\/div> <\/div><\/div>    <section class=\"wp-block-breadcrumbs\">   <div class=\"content-wrapper\">     <ul>                   <li>               <a href=\"https:\/\/www.ginefiv.com\/en\/\" title=\"Ginefiv Espa\u00f1a\">                 Ginefiv              <\/a>             <\/li>                         <li>               <span class=\"current\" title=\"MACS\">                 MACS              <\/span>             <\/li>                 <\/ul>   <\/div> <\/section>    <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <p>The MACS (Magnetic Activated Cell Sorting) technique is especially suitable for cases of male infertility in which there is a percentage of pathological <a href=\"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/sperm-dna-fragmentation-testing\/\">sperm DNA fragmentation<\/a>. It can improve the fertilisation rate by up to 13% in both <a href=\"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/in-vitro-fertilization\/\">IVF<\/a> and <a href=\"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/artificial-insemination\/\">artificial insemination<\/a> treatments.<\/p> <\/div> <\/div>    <div class=\"wp-block-columns alignfull has-turquoise-teal-background-color has-background is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <section class=\"grid-icons-block content-wrapper\">        <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         35 years of experience      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Safety Guaranteed      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Top quality care      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Cutting edge technology      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         High success rates      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Affordable prices      <\/div>     <\/div>     <\/section><\/div> <\/div>    <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <h3 class=\"wp-block-heading\">What is the MACS technique?<\/h3> <\/div> <\/div>    <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\"> <iframe loading=\"lazy\" title=\"MACS\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/H8nyqvujf_0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe> <\/div><\/figure> <\/div>    <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <p>MACS enables the immunomagnetic selection of healthy spermatozoa that are optimal for egg fertilisation, separating them from those with apoptotic markers which indicate that the spermatozoon will most likely die. This technique is especially designed for use in <a href=\"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/artificial-insemination\/\">artificial insemination<\/a> as well as in <a href=\"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/in-vitro-fertilization\/\">IVF<\/a> and <a href=\"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/icsi\/\">ICSI<\/a> treatments.<\/p>    <p>Apoptosis or programmed cell death is a process for controlling the cell lifecycle. It starts during spermatogenesis, when cellular damage such as <a href=\"https:\/\/www.ginefiv.com\/en\/assisted-reproduction\/sperm-dna-fragmentation-testing\/\">sperm DNA fragmentation<\/a>, for example, is detected.<\/p> <\/div> <\/div>    <section  class=\"banner-testimonies-block-container\">     <div class=\"banner-testimonies-bg\" style=\"background-image:url(https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/bg-testimonial-logo.svg)\"><\/div>     <div class=\"banner-testimonies-block\">         <div class=\"banner-testimonies-block__content\">             <!--h3 class=\"testimonies-block__title heading-md\"-->                 Dreams that came true            <!--\/h3-->             <div class=\"testimonies-block__cards-container\" data-slider=\"testimony\">                                     <div class=\"testimony\">                         <img decoding=\"async\" class=\"testimony__decorator\" src=\"https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/icons\/testimony_decorator.png\" alt=\"Testimony decorator\">                         <div class=\"testimony__text\">                             <p>We went to Ginefiv because it worked for a few of my friends and they are mums<br \/> now. The prognosis wasn\u2019t very favourable because my ovarian reserve was low, but<br \/> the doctor told us that the eggs might be good quality.<\/p> <p>I went for my first insemination and it was really emotional knowing that it was virtually impossible that it would happen on the first try, but at the beta test I already<br \/> suspected that I was pregnant. And they gave us the news we had been hoping for:<br \/> we were pregnant! Yes, it worked on the first go.<\/p> <p>Our little Olivia was born nine months later and we couldn\u2019t be more in love<\/p>                         <\/div>                         <p class=\"testimony__author\">                             Mar\u00eda y Rodrigo                        <\/p>                     <\/div>                                     <div class=\"testimony\">                         <img decoding=\"async\" class=\"testimony__decorator\" src=\"https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/icons\/testimony_decorator.png\" alt=\"Testimony decorator\">                         <div class=\"testimony__text\">                             <p>We were advised to get IVF with microinjection and we got good embryos from it.<\/p> <p>Three of these \u2018little ones\u2019 were transferred to me and I became pregnant with Cristina.<\/p> <p>It all went so well and it was so easy that after 15 months we decided to go for a little<br \/> brother. It didn\u2019t happen at first but we were lucky on the third try with frozen<br \/> embryos and we had our second child, Carolina. We couldn\u2019t be happier<\/p>                         <\/div>                         <p class=\"testimony__author\">                             Pilu                        <\/p>                     <\/div>                                     <div class=\"testimony\">                         <img decoding=\"async\" class=\"testimony__decorator\" src=\"https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/icons\/testimony_decorator.png\" alt=\"Testimony decorator\">                         <div class=\"testimony__text\">                             <p>We were fed up with another clinic so we came here and what a good move that<br \/> was. I couldn\u2019t get pregnant even after months and months, and the tests showed<br \/> there was nothing stopping it.<\/p> <p>After a while though, it did happen for us. And even though I spent so long worrying<br \/> about my health, thinking about my baby changed my mood completely.<\/p> <p>Thank-you all for the hard work.<\/p>                         <\/div>                         <p class=\"testimony__author\">                             Carla Ruiz                        <\/p>                     <\/div>                                     <div class=\"testimony\">                         <img decoding=\"async\" class=\"testimony__decorator\" src=\"https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/icons\/testimony_decorator.png\" alt=\"Testimony decorator\">                         <div class=\"testimony__text\">                             <p>We were recommended to go to Ginefiv by some friends and after our first visit,<br \/> looking at other clinics didn\u2019t even cross our minds.<\/p> <p>We went there after 7 years of unsuccessful treatments with the Social Security<br \/> healthcare system.<\/p> <p>At Ginefiv I got pregnant with the second transfer.<\/p> <p>I\u2019ve only got good things to say about Ginefiv and the way they took care of us. We<br \/> found the best clinic and doctor in the world<\/p>                         <\/div>                         <p class=\"testimony__author\">                             Roberto y Aurora                        <\/p>                     <\/div>                             <\/div>         <\/div>     <\/div> <\/section>   <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <p>In various studies of males with infertility, it has been found that their ejaculate contains a high number of spermatozoa which have apoptotic markers, which therefore means that the control mechanism itself has not functioned correctly, or else there are a high number of damaged cells. This may be due to both intrinsic and extrinsic factors (smoking, stress, fever, varicocele, etc.).<\/p>    <p>In this context we turn to immunomagnetic cell selection, a.k.a. MACS. In thistechnique, spermatozoa pass through a magnetised column in such a way that thosewith apoptotic markers in their membranes are retained in the filtration columnthrough which the sperm sample passes, whilst the healthy spermatozoa which aresuitable for egg fertilisation are let through. This selection improves the fertilisationrate by up to 13%<\/p> <\/div> <\/div>    <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\" id=\"en-que-consiste\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"450\" height=\"253\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/MACS-content-01.webp\" alt=\"\" class=\"wp-image-4197\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/MACS-content-01.webp 450w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/MACS-content-01-300x169.webp 300w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/figure> <\/div>    <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <h3 class=\"wp-block-heading\">What does the MACS technique consist of?<\/h3>    <p>The technique is based on the use of magnetic microspheres which are conjugated to molecules of Annexin V which in turn recognise and adhere to the phosphatidylserine in the membrane of the spermatozoa.<\/p>    <p>Phosphatidylserine is an early marker of cellular apoptosis, seeing as in healthy cells this phospholipid is found towards the interior of the membrane, but when apoptosis begins in the cell, the molecule moves outwards.<\/p>    <p>Therefore, we can use MACS to indicate the presence of spermatozoa with this marker because when they are made to pass through the magnetised column, they are retained within it, allowing us to separate them from the healthy spermatozoa.<\/p> <\/div> <\/div>    <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <h3 class=\"wp-block-heading\">When should the MACS technique be used?<\/h3>    <p>This technique is especially suited to the following cases:<\/p>    <ul class=\"wp-block-list\"> <li>Patients who have been diagnosed with pathological sperm DNA fragmentation.<\/li>    <li>Patients who have undergone more than two treatment cycles without gestation.<\/li>    <li>Patients with recurrent miscarriage<\/li> <\/ul> <\/div> <\/div>    <section> \t<div class=\"cta-block-container\"> \t\t<div class=\"cta-block-container__title\"> \t\t\t<p><h2><span dir=\"ltr\" role=\"presentation\">Any questions?<\/span><\/h2> <\/p> \t\t<\/div> \t\t<div class=\"cta-block-container__separator d-none d-md-flex\"> \t\t\t<picture> \t\t\t\t<img decoding=\"async\" class=\"separator__img\" src=\"https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/icons\/cta-separator.webp\" alt=\"\"> \t\t\t<\/picture> \t\t<\/div> \t\t<div class=\"cta-block-container__icons-row\"> \t\t\t\t\t\t\t<div class=\"actions\"> \t\t\t\t\t<picture class=\"action__thumbnail\"> \t\t\t\t\t\t<img decoding=\"async\" class=\"action__img\" 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