{"id":5586,"date":"2023-10-10T10:57:29","date_gmt":"2023-10-10T10:57:29","guid":{"rendered":"https:\/\/www.ginefiv.com\/treatment\/macs\/"},"modified":"2024-02-12T08:04:22","modified_gmt":"2024-02-12T08:04:22","slug":"macs","status":"publish","type":"treatment","link":"https:\/\/www.ginefiv.com\/it\/riproduzione-assistita\/macs\/","title":{"rendered":"MACS"},"content":{"rendered":"<section class=\"page-cover treatment-section has-thumbnail dark-theme\">     <div class=\"page-cover__container container treatment-page\">         <div class=\"row\">             <div class=\"col-12 col-lg-6 pt-4 pt-lg-0\">                 <div class=\"page-cover__heading\">                     <div class=\"page-cover__heading-wrapper treatment-heading\">                                                   <div class=\"page-cover__heading-subtitle heading-subtitle text-xxl\">                             <p>Riproduzione assistita<\/p>                         <\/div>                          <div class=\"page-cover__heading-title heading-title title-display\">                             <h1 class=\"title-display\">MACS (Magnetic Activated Cell Sorting)<\/h1>                         <\/div>                                                      <div class=\"page-cover__heading-content text-lg\">                                 <p>Come vediamo a continuazione, la tecnica MACS permette ottimizzare la selzione spermatica prima di utilizzare le techniche di riproduzione assistita.<\/p>                             <\/div>                                                                      <\/div>                 <\/div>             <\/div>              <div class=\"col-12 col-lg-6 pt-5 pt-lg-0 pl-lg-5\">                 <div class=\"treatment-links-container\">                                             <div class=\"treatment-links-container__links text-lg\">                             <ul> <li><a href=\"#cose\" rel=\"noopener\"> Cos&#8217;\u00e8 il MAC?<\/a><\/li> <li><a href=\"#quale\" rel=\"noopener\">Qual \u00e8 la tecnica?<\/a><\/li> <li><a href=\"#quando\" rel=\"noopener\">Quando \u00e8 indicato?<\/a><\/li> <\/ul>                         <\/div>                                     <\/div>             <\/div>         <\/div>     <\/div>               <div class=\"parallax-trigger fullsize page-cover-thumbnail treatment-thumbnail\" data-magic=\"parallax\">             <picture class=\"page-cover__picture parallax-trigger__item\" data-item=\"parallax-item\">                 <img decoding=\"async\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/06\/inseminacion_hero.webp\" alt=\"MACS\">             <\/picture>         <\/div>       <\/section>   <section class=\"wp-block-breadcrumbs\">   <div class=\"content-wrapper\">     <ul>                   <li>               <a href=\"https:\/\/www.ginefiv.com\/it\/\" title=\"Ginefiv Espa\u00f1a\">                 Ginefiv              <\/a>             <\/li>                         <li>               <span class=\"current\" title=\"MACS\">                 MACS              <\/span>             <\/li>                 <\/ul>   <\/div> <\/section>    <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <p>Questa tecnica di selezione MACS \u00e8 particolarmente indicata nei casi di infertilit\u00e0 maschile con percentuali di alta frammentazione dna spermatica patologica; \u00e8 pensata per essere utilizzata sia nei trattamenti di inseminazione artificiale sia per la fecondazione in vitro e migliora i risultati di fecondazione fino a 13%.<\/p> <\/div> <\/div>    <div class=\"wp-block-columns alignfull has-turquoise-teal-background-color has-background is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"> <section class=\"grid-icons-block content-wrapper\">        <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/35anos-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         35 anni di esperienza      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-cruz-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Seguridad garantizada      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/auriculares-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Assistenza personalizzata      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/ovulo-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Tecnologia in prima linea      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/medalla-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Alte percentuali di successo      <\/div>     <\/div>         <div class=\"grid-icon\">             <picture class=\"grid-icon__thumbnail\">         <img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok.png 700w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok-300x300.png 300w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok-150x150.png 150w, https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/mano-ok-420x420.png 420w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/>      <\/picture>             <div class=\"grid-icon__text\">         Tariffe economiche      <\/div>     <\/div>     <\/section><\/div> <\/div>   <section id=\"cose\" class=\"video-text-block custom-block-spacing\">     <div class=\"container\">                     <div class=\"row\">                 <div class=\"title-col col-12\"><h3 class=\"title-display\">Che cos\u2019\u00e8 il MACS?<\/h3> <\/div>             <\/div>                  <div class=\"row\">             <div class=\"video-col col-12 col-md-6\">                 <iframe loading=\"lazy\" title=\"MACS\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/JjhCjIaTTCs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>            <\/div>             <div class=\"text-col col-12 col-md-6\">                 <div class=\"video-text-block__text-wrapper\">                                         <p>\u00c8 una tecnica che permette la selezione immunomagnetica di spermatozoi sani e ottimi per la fertilizzazione dell\u2019ovulo separandoli da quelli con marcatori apoptotici, destinati a morire. Questa tecnica \u00e8 specialmente adatta per la sua utilizzazione in trattamenti sia di inseminazione artificiale come di Fecondazione \u201cin Vitro\u201d o Microiniezione degli spermatozoi.<\/p> <p>La apoptosi, \u00e8 anche conosciuta come morte cellulare programmata, \u00e8 un procedimento di controllo del ciclo cellulare. Durante la spermatogenesi, si inizia, per esempio, all\u2019avvertire danni cellulari come la frammentazione dell\u2019ADN degli spermatozoi.<\/p>                 <\/div>             <\/div>         <\/div>     <\/div> <\/section>   <section  class=\"banner-testimonies-block-container\">     <div class=\"banner-testimonies-bg\" style=\"background-image:url(https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/bg-testimonial-logo.svg)\"><\/div>     <div class=\"banner-testimonies-block\">         <div class=\"banner-testimonies-block__content\">             <!--h3 class=\"testimonies-block__title heading-md\"-->                 Sogni compiuti            <!--\/h3-->             <div class=\"testimonies-block__cards-container\" data-slider=\"testimony\">                                     <div class=\"testimony\">                         <img decoding=\"async\" class=\"testimony__decorator\" src=\"https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/icons\/testimony_decorator.png\" alt=\"Testimony decorator\">                         <div class=\"testimony__text\">                             <p><span>\u201cun&#8217;equipe perfetta&#8230;.in primis la dottoressa D&#8217;aurelio che ha seguito il nostro caso con grande determinazione e professionalit\u00c3 . Oggi, mia moglie, \u00c3\u00a8 entrata nel V mese di gravidanza. Premetto che, prima di approdare in Spagna, abbiamo girato in lungo e in largo l&#8217;Italia senza risparmiarci di consultare i migliori medici del nostro territorio. Poi, quando meno te l&#8217;aspetti, una nostra concittadina, ha compiuto un vero e proprio miracolo. Per noi rimarr\u00c3 per sempre un&#8217;esperienza fantastica!!!!\u201d<\/span><\/p>                         <\/div>                         <p class=\"testimony__author\">                             Sicur Med                        <\/p>                     <\/div>                                     <div class=\"testimony\">                         <img decoding=\"async\" class=\"testimony__decorator\" src=\"https:\/\/www.ginefiv.com\/wp-content\/themes\/wac-theme\/assets\/images\/icons\/testimony_decorator.png\" alt=\"Testimony decorator\">                         <div class=\"testimony__text\">                             <p><span>\u201cCiao a tutti La mia esperienza con Ginefiv \u00e8 stata estremamente positiva in quanto ho fatto due tentativi entrambi andati bene anche se durante il primo ho avuto un aborto spontaneo ( ma il transfer era ok ) e dopo alcuni mesi sono rimasta di nuovo incinta. Dunque la mia percentuale di successo \u00e8 stata il 100%. A settembre \u00e8 nato un bellissimo bambino di 4240 grammi di nome Simone. Il personale ha attenzioni, competenze e ti segue in tutto il tuo percorso, passo dopo passo, parlando la tua lingua. Anche se si vive in un&#8217;altro stato \u00e8 molto semplice fare il primo colloquio e tramite email o skype essere in contatto con loro. \u201d<\/span><\/p>                         <\/div>                         <p class=\"testimony__author\">                             Sabrina                        <\/p>                     <\/div>                             <\/div>         <\/div>     <\/div> <\/section>  <section  class=\"text-block background-light custom-block-spacing\">   <div class=\"container\">     <div class=\"row\">       <div class=\"col-12\">         <div class=\"text-block__text-wrapper text-heading-block alignment-left\" data-magic=\"appear-in\">                     <p>In diversi studi con pazienti affetti da infertilit\u00e0, si \u00e8 visto che riscontrava un elevato numero di spermatozoi che rivelano marcatori apoptotici, e che in conseguenza, il meccanismo di controllo proprio non ha funzionato correttamente o il tasso di cellule dannate \u00e8 molto elevato. Questo pu\u00f2 essere causato sia da fattori intrinseci sia da fattori esterni (consumo di tabacco, stress, febbre, varicocele, ecc\u2026).<\/p> <p>Per questi casi esiste una tecnica complementare utilizzata, chiamata MACS per selezionare magneticamente gli spermatozoi sani pi\u00f9 adatti per fertilizzare l\u2019ovocito. Gli spermazozoi passano attraverso una colonna magnetizzata, separandoli da quelli che presentano marker apoptotici nella membrana, che vengono ritenuti e filtrati e si utilizzano poi soli gli spermatozoi liberei e sani, adatti per la fertilizzazione. Questa selezione migliora il risultato fino a 13%<\/p>                   <\/div>       <\/div>     <\/div>   <\/div>  <\/section>  <section id=\"quale\" class=\"image-text-block custom-block-spacing align-left\" data-magic=\"float-zigzag\">   <div class=\"container\">         <div class=\"row\">       <div class=\"img-col col-12 col-md-6\">                   <picture class=\"image-text-block__img-wrapper image-wrapper zigzag-element\">                         <img data-src=\"https:\/\/www.ginefiv.com\/wp-content\/uploads\/2023\/10\/MACS-content-01.webp\" alt=\"\">           <\/picture>               <\/div>       <div class=\"text-col col-12 col-md-6\">         <div class=\"image-text-block__text-wrapper text-heading-block zigzag-element\">           <div class=\"image-text-block__text-wrapper__content\">             <div class=\"text-block-wrapper\">                             <h3 class=\"title-display\">In cosa consiste la tecnica?<\/h3>               <p>La tecnica si basa nell\u2019utilizzazione di micro-sfere magnetiche, che portano incollate nella sua parete molecole specifiche (Annexin V) capaci di riconoscere diversi marcatori nella membrana degli spermatozoi. Uno dei marcatori che si manifesta nelle cellulle spermatiche apoptotiche \u00e8 la presenza di residui di fostatidilserina nella membrana esterna che all\u2019essere riconosciuti per gli anticorpi incollati alle micro-sfere e passargli per un campo magnetico, permetter\u00e1 la separazione dal resto degli spermatozoi sani.In questo modo con il MACS possiamo identificare questi marcatori negli spermatozoi e al farli passare attraverso la colonna, sarano ritenuti, quello che permette separarli deglispermatpzoi sani.<\/p>             <\/div>                       <\/div>         <\/div>       <\/div>     <\/div>   <\/div>  <\/section>  <section id=\"quando\" class=\"text-block background-light\">   <div class=\"container\">     <div class=\"row\">       <div class=\"col-12\">         <div class=\"text-block__text-wrapper text-heading-block alignment-left\" data-magic=\"appear-in\">                     <h3 class=\"title-display\">Quando \u00e8 indicato?<\/h3> <p>Questa tecnica \u00e8 specialmente indicata nei seguenti casi:<\/p> <ul> <li>Pazienti con risultato frammentazione di dna spermatico patologico<\/li> <li>Pazienti con pi\u00f9 di due cicli di trattamento senza gravidanza<\/li> <li>Pazienti con aborti di ripetizione<\/li> <\/ul>                   <\/div>       <\/div>     <\/div>   <\/div>  <\/section>   <div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\"> <div class=\"wp-block-column wp-column-is-centred is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:610px\"> <h3 class=\"wp-block-heading has-text-align-center\" id=\"fissare\">Fissa un appuntamento con uno specialista<\/h3>    <p class=\"has-text-align-center\">Richieda di avere una consulenza in clinica o per videoconferenza, l&#8217;opzione che sia pi\u00fa conveniente per Lei<\/p>    <div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 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